Pancreatic enzyme replacement therapy for steatorrhoea in pancreatic cancer

Pancreatic Replacement Therapy in the Treatment of Pancreatic Steatorrhoea.

The effect of a whole pancreas preparation (Viokase) has been investigated in 11 patients with pancreatic steatorrhoea and in five patients with steatorrhoea due to other causes. The appearance of the stool, faecal fat, and stool and blood radioactivity after a given dose of I(131) triolein (Raolein) were employed in assessing the response to Viokase therapy. Pancreatic steatorrhoea was conside...

Pancreatic Enzyme Replacement Therapy

Patients with chronic pancreatic insufficiency develop improper digestion due to the lack of digestive pancreatic enzymes. Such patients might complain of diarrhea and multi-nutrient deficiencies. Children with cystic fibrosis are at an increased risk of developing pancreatic insufficiency, while adults can develop chronic pancreatitis due to gallbladder disease or alcohol consumption. Regardle...

Pancreatic enzyme therapy for pancreatic exocrine insufficiency.

Pancreatic exocrine insufficiency with steatorrhea is a major consequence of pancreatic diseases (eg, chronic pancreatitis, cystic fibrosis, severe acute necrotizing pancreatitis, pancreatic cancer), extrapancreatic diseases such as celiac disease and Crohn's disease, and gastrointestinal and pancreatic surgical resection. Recognition of this entity is highly relevant to avoid malnutrition-rela...

Enzyme replacement therapy for pancreatic insufficiency: present and future

Pancreatic enzyme replacement therapy is currently the mainstay of treatment for nutrient malabsorption secondary to pancreatic insufficiency. This treatment is safe and has few side effects. Data demonstrate efficacy in reducing steatorrhea and fat malabsorption. Effective therapy has been limited by the ability to replicate the physiologic process of enzyme delivery to the appropriate site, i...

Decrease in pancreatic steatorrhoea by positioned-release enzyme capsules.